Even while standing at the door of his 100th international century, Master Blaster Sachin Tendulkar is insisting the huge milestone would not be on his mind when India take the field against England in the first Test at Lord’s, London, on July 21.Having cracked 51 centuries in 177 Tests and 48 in 453 One-Day Internationals, Tendulkar feels rather than the records, it’s the impression that he leaves behind is more important.Sachin Tendulkar wants to enjoy batting during India tour of England. AP”I’m not thinking of records. I’m just thinking of enjoying this tour. The secret to any performance is not in chasing records. I think about, ‘What is the best way to enjoy the game, and how can I enhance that enjoyment factor?” he was quoted as saying by London’s Daily Telegraph.”If I enhance the enjoyment then, naturally, the standard of play becomes higher. To me, that is more important. If I’m playing well, things can happen. I don’t need to go around chasing them. It’s a process. You construct a solid foundation and build on it.”Tendulkar said he is keen to contribute to the team’s cause. “For me, it’s not about breaking records or creating new ones. It’s about adding value to my team. Records will be set by me; they might be broken by someone else,” he averred.”They’re not going to stay permanently. But the impression that I leave on people will last forever, I feel. The impression that I leave behind – to me that is important. If I can motivate the next young cricketers, that will be a big contribution.”advertisementIn England for the last few weeks, preparing for the four-Test series, Tendulkar said he is accustomed to the pressure.”I’m used to it. It’s the kind of lifestyle that I lead in India. It began around the age of 16, at the time I would start going out and mixing with friends. But I don’t feel suffocated. I feel extremely comfortable back home in whatever I do. That’s how my life has been, so I believe it’s normal,” he said.”I have been rewarded, and God has been kind to me. I have no complaints. I am very grateful to all the people who have appreciated and supported me over the years, and who have accepted me in the manner that I am.”Tendulkar, 38, who recently changed his hairstyle, often visits England during the summer and he now owns a flat at St John’s Wood in London.”When I spend time in England, it’s different. I get to do certain things that I wouldn’t be able to do in India: to go into the park with my children, to do whatever they want to do, whether it be a game of soccer or cricket. I enjoy the best of both. The idea is to balance life in India with life away from India, to get the best of both and to be a happy man,” he said.The former India captain once again stressed that being part of the World Cup-winning team gave him immense happiness and that retirement was not on his mind as yet.”I was extremely delighted. It was something I had always dreamt about. You start playing cricket, and one day you walk away as part of a world champion team,” he said of the triumph in April in his home city Mumbai.If the last statement gave you ideas about his retirement, Tendulkar was quick to set the record straight. “I haven’t,” he said of a decision on retirement.”I’m enjoying every moment. It has been fun. In fact, I’m looking at how to enjoy the game more and how to improve the standard of play. It’s about getting better. Nobody knows what is going to happen tomorrow. At least today I know that I want to enjoy cricket, to enjoy the moment.”
Mumbai, Mar 27 (PTI) Mid-last year, Indias nascent climbing sport segment scored big by winning the bid to host the International Federation of Sports Climbing (IFSC) World Cup for bouldering in the satellite city of Navi Mumbai in May 2016. But the encouraging move has not yet translated into getting state administration as well as the large corporates to open their purse-strings, forcing the organisers to seek crowd-funding to meet the huge expenses which will run to crores of rupees. Only government-run Cidco has agreed to offer its exhibition centre at Vashi for the event to be held for the first time ever. For the over 50-year-old Girivihar Adventure Club, the organisers for the meet hosted by Indian Mountaineering Federation, this was a big leap. “India is only the fourth Asian country to have bagged a Climbing World Cup and its a huge honour. It is heartening to note that Indians are slowly opening up to newer sports and sometimes it is events like this that can exponentially increase their interests,” Abhijit Burman of Girivihar told PTI over the weekend.Burman cites how for cricket, the win by Kapil Devs team in 1983, followed by co-hosting the World Cup in 1987, worked wonderfully well.Specially-made walls will be erected at an indoor facility on which the climbers will be competing for the top honours this May.The International Federation of Sports Climbing has 83 member-countries and there are eight such IFSC world cups being held across the world every year.But for the three-day extravaganza arranging finances in India has become a formidable challenge for the organisers.advertisementThe Maharashtra government-run City Industrial Development Corporation (Cidco) was the first to come forth and provide the fully air-conditioned, state-of-the-art Cidco Exhibition Center at Vashi as the venue for the event.Corporate sponsors are coming forth but are shying away from large sponsorship amounts, the organisers rue. (MORE) PTI AA BEN ARS SSC SSC
OTTAWA – Facebook founder Mark Zuckerberg made a public apology Wednesday for his company’s handling of users’ personal information — including more than 620,000 Canadians — as the social media giant faced a growing international uproar over the questionable use of personal data for political purposes.The company estimates 622,161 users in Canada had their data improperly shared with Cambridge Analytica through apps used by themselves or their friends.Overall, Facebook says that 87 million of its users worldwide were affected — significantly more than the 50 million originally believed to be affected — with nearly 82 per cent of them believed to be located in the United States.The company said those affected will find out Monday if their information was improperly shared with Cambridge Analytica.Zuckerberg said the privacy breach showed his company didn’t take seriously its responsibility towards users “and that was a huge mistake.”“It was my mistake. So now we have to go through every part of our relationship with people and make sure we’re taking a broad enough view of our responsibility,” he said during an afternoon conference call with reporters.“It’s not enough to just connect people. We have to make sure those connections are positive and that they bring people closer together.”Canada’s privacy commissioner said he wasn’t surprised at the magnitude of the number of Canadians affected. Speaking in Toronto, Daniel Therrien said the figure will work into his ongoing investigation about the data breach and whether there were any violations of federal privacy laws.Facebook is facing its worst privacy scandal ever in the wake of allegations that Cambridge Analytica used data collected without users’ authorization to help Donald Trump’s 2016 presidential campaign and possibly other elections. Policy makers in Canada and other countries are now wrestling with how to respond to the spread of “fake news” on social media platforms like Facebook, which announced Wednesday it had also shut down accounts and pages linked to a Russian agency accused of online meddling in foreign elections.Zuckerberg said the company would bring to 20,000 the number of workers dedicated to battling “fake news,” as he apologized for initially dismissing the notion that the misinformation campaign had any impact on election outcomes.The social media giant plans to restrict data access on its platforms, which includes Instagram, to better protect users’ information. Facebook will disable a feature that let anyone search Facebook for a user with their email or phone number, saying in a post that “malicious actors” had used the tool to scrape personal data of most users on Facebook. And starting Monday, it will show people which apps use their Facebook information.Zuckerberg is set to testify next week before a U.S. congressional committee, and he said top executives at the company would be dispatched to other countries wanting to hold government hearings on the scandal.Canada’s acting minister for democratic institutions called Facebook’s admission of the scope of the breach “deeply concerning.”“While Facebook has begun to take initial steps to address these issues, it is clear that much more needs to be done,” Scott Brison said in a statement.Brison has said he’d be open to strengthening federal privacy laws, which don’t currently apply to political parties. And Zuckerberg appeared open to further regulation in a sector that has so far shied away from government oversight.International experts in the national capital Wednesday to talk about the issue of “fake news” said the Liberals needed to enact stronger privacy laws to better regulate how social media giants use Canadians’ personal information.“Since there are insufficient limits on what you can do with personal data, there is no countervailing force,” said David Carroll, an American academic who is suing Cambridge Analytica in the U.K. to gain access to his data.“We need to realize that privacy legislation will weaken the behemoths in a healthy way.”Other options put forward included greater transparency for online advertising that would enable users to easily learn who paid for a Facebook ad, how much they spent, how many people viewed it and why the ad targeted the user. Ben Scott, a former adviser in the State Department, said countries should look for ways to restrict the use of personal data for political targeting to avoid the kind of dirty tricks campaigns Cambridge Analytica is accused of conducting.Sue Gardner, former executive director of Wikimedia Foundation, said there is general opposition south of the border to government regulations in the sector, with a belief that government involvement would make matters worse. Instead, recommendations in the U.S. centre around self-regulation.“Those are massively insufficient for the scope of the problem,” she said.— With files from Andy Blatchford in Ottawa and Dave Paddon in Toronto
VICTORIA, B.C.- Raises are coming for alternate minimum wage earners. Liquor servers, piece-rate farmers, resident caretakers, and live in camp leaders will all soon see a pay raise. The news was announced today by the Minister of Labour Harry Bains.“No one working for minimum wage, full-time, year-round should be living in poverty. Workers deserve a minimum level of protections that regardless of a person’s job description, they don’t earn a wage that is distinctly less then the general minimum wage.” Stated Baines.Liquor servers, resident caretakers and live in camp leaders will all see wage increases as of June 1st 2018, while farm workers paid by the piece rate will see an increase as of January 1st, 2019. Agricultural Minister Lana Popham said the government is extending the transition period for changes to the farm worker piece rate to January 2019, from June 2018, in order to better balance the needs of workers and the agricultural industry. Wages for the five worker groups will increase like this: Liquor servers – incremental increases on June 1 each year, beginning June 2018, until the general minimum wage is reached, of at least $15.20 per hour, in 2021. Piece-rate farm workers – 11.5% increase to all piece rates on Jan. 1, 2019, with further study to take place. Resident caretakers – 11.5% increase June 2018, followed by increases of 9.5%, 5.4% and 4.1% in 2019, 2020 and 2021, respectively (wages vary depending on building size). Live-in camp leaders – same per cent increases as resident caretakers, until they reach $121.65/per day, in 2021. Live-in home-support workers – abolishment of the alternate minimum wage for this group, as it covers very few or no workers. The general minimum wage will apply to any workers remaining in this category.In February 2018 the Fair Wages Commission had two tasks, first to recommend a pathway to raise general minimum wage to 15$-an-hour. The second task was to provide recommendations on groups of workers whose minimum wage is different from the general wage. These workers were liquor servers, farm workers paid by piece rates, resident caretakers, live-in camp leaders, and live-in home support workers.
New Delhi: Several parts of north India continued to reel under scorching heat on Wednesday with Jammu recording its season’s hottest day at over 40 degrees Celsius, according to the Meteorological Department.Heat wave was observed at isolated places in west Rajasthan where Sri Ganganagar became the hottest place at a maximum of 45.6 degrees Celsius. Churu, known for its extreme weather conditions, recorded a maximum of 44.5 degrees Celsius, becoming the second hottest place in the state. Also Read – 2019 most peaceful festive season for J&K: Jitendra SinghThe weather remained dry in the desert state even as Met officials warned that heat wave conditions would likely occur at isolated places in west Rajasthan during the next 48 hours. Jammu, the winter capital of Jammu and Kashmir, for the first time this season, crossed the 40 degrees Celsius. The maximum temperature recorded in Jammu was 40.1 degrees Celsius — 3.3 notches above the normal during this time of the season, a Met Department official said. Also Read – Personal life needs to be respected: Cong on reports of Rahul’s visit abroadHe said the minimum temperature in the city also continued its upward trend and settled at 25.5 degrees Celsius, which is 2.5 degrees above the normal. Residents of the national capital continued to reel under sweltering conditions with the mercury crossing the 43-degrees mark in some parts of the city. The Safdarjung observatory, recording of which is considered the official figure for the city, recorded a maximum temperature of 41.8 degrees Celsius, three notches above the season’s average, said a Met department official, adding that the minimum temperature was recorded at 23.6 degrees Celsius, a notch below the normal. The Palam observatory registered a high of 43.6 degrees Celsius. Heat wave conditions persisted in Telangana where Nalgonda sizzled with the highest maximum temperature of 45 degrees Celsius. The India Meteorological Department said heat wave conditions are very likely to prevail over some parts of the state on May 9 and May 10. It also warned that thunderstorm accompanied with gusty winds (40 to 50 kmph) and lightning are very likely to occur at isolated places over Telangana. Several parts of Himachal Pradesh reeled under scorching heat with Una recording a high of 41 degrees Celsius, the highest temperature in the Himalayan state. The maximum temperatures have increased by one to two degrees Celsius in the state during the last 24 hours, Shimla centre MeT director Manmohan Singh said. The maximum temperature was 37.7 degrees Celsius in Bilaspur, 36.4 degress Celsius in Hamirpur, 35.5 degrees Celsius in Chamba and 32.5 degrees Celsius in Solan.
1. How will quarterback Terrelle Pryor be used, and how effective will he be?The better question might be, will he have an opportunity to?Pryor fought through an ankle injury for the majority of the second half of the season, and coach Jim Tressel compensated for his hampered mobility by calling more rushing plays. Pryor attempted 17 passes in each of Ohio State’s last three games, victories over Penn State, Iowa and Michigan. In those contests, the Bucks ran the ball 49, 51 and 53 times, respectively.Now, Pryor revealed that he has been suffering through a torn ligament in his knee, though both he and Tressel have firmly maintained that the injury won’t limit him Friday.“He’s very healthy,” Tressel told the media Thursday. “He can move around very, very well.”Centering on the ground game certainly benefitted the Buckeye offense, however. The team rushed for at least 225 yards in each of its last five contests, all wins. Pryor, who threw just four interceptions during his freshman campaign, tossed nine in the first eight games this season.But ever since the Bucks reverted to a run-heavy attack, Pryor has committed just one turnover in four contests.Pryor has apparently cleaned up his mechanics after a sloppy start to the season, with help from a dependable rushing attack. Whether or not he will be asked to carry more of the offensive burden lies within Tressel’s trust of his progressing quarterback.2. Can the Buckeyes slow down an up-tempo Oregon offense?The Ducks posted 37.7 points per game during the regular season, even after being limited to eight points in a season-opening loss at Boise State.While the Buckeyes tend to methodically inch toward the end zone, the Ducks rarely waste any time putting points on the board.In its 47-20 victory over USC on Oct. 31, Oregon recorded three drives covering 80 or more yards. Each series resulted in a touchdown, and each lasted fewer than three minutes.When the Ducks piled up 42 points in a Nov. 7 loss to Stanford, they continuously struck immediately. Oregon scored a touchdown at the end of a 93-yard drive that lasted just one minute and 16 seconds. The Ducks scored five touchdowns following that lengthy drive, the five drives lasting eight seconds, two minutes and 43 seconds, one minute and 46 seconds, two minutes and 43 seconds and 52 seconds, respectively. That’s six touchdowns in eight minutes and 59 seconds. In the longest of the six drives, which persisted for two minutes and 43 seconds, the Ducks squeezed in 12 plays.Clearly, the Oregon offense moves rapidly and effectively.Still, Tressel believes that if necessary, Oregon could sustain a lengthy drive just as successfully.“All you have to do is go back to their last game [against Oregon State], and they needed to keep the ball for five or six minutes,” Tressel said. “They can possess the ball if they’d like. And in that case, the game ended where I don’t think Oregon State got another chance with the ball.” 3. Will Ohio State suffer from the absences of Ray Small, Duron Carter and Rob Rose?“We are definitely going to miss them,” receiver DeVier Posey said. “But we still have a game. I love those guys to death, I miss them on the trip, but we still have to play.”The trio were suspended for the Rose Bowly. Small and Carter, the team’s No. 3 and No. 4 receivers, respectively, during the regular season, only combined for 28 catches. In their place, Lamaar Thomas and Taurian Washington, both frustrated about their lack of playing time, will see the field.“They got an opportunity now and they’ll show up,” Pryor said about his new set of weapons on offense. “They’ll catch the ball.”Along the defensive line, the Buckeyes have plenty of bodies to rotate in to replace Rose’s production. Defensive tackle Dexter Larimore will return from a knee injury, and defensive coordinator Jim Heacock can substitute a number of players at the end position, where Rose typically lines up.“We got [Defensive lineman] Garrett [Goebel] stepping up and Johnny [John Simon] is playing a little end,” senior defensive end Lawrence Wilson said. “We got guys stepping up and filling in [Rose’s] place. We should be fine at the end spot.”
Ohio State announced Ryan Day, along with Greg Schiano, will become the first million-dollar assistant coaches in Ohio State football history on Feb. 14. Credit: Jack Westerheide | Photo EditorAfter paying $700,000 in base salary for its highest-paid assistant coach last season, Ohio State will pay two assistant coaches — associate head coach and defensive coordinator Greg Schiano and offensive coordinator and quarterbacks coach Ryan Day — at least $1 million in 2018, the university announced Wednesday. Schiano earned more money than any other Buckeye assistant coach last season and will remain the highest-paid assistant, earning $1.5 million next season in base salary on a one-year deal. His $800,000 raise is a larger sum of money than his 2017 base salary of $700,000. Schiano had been pursued by teams in the NFL as an assistant coach and in the NCAA as a head coach.Day, who was promoted from co-offensive coordinator to offensive coordinator after the season, will earn a $1 million base salary next season. He signed a three-year deal, according to Ohio State.Ohio State co offensive coordinator Greg Schiano (middle, in red), leads into the air after the Buckeyes beat Penn State 39-38 on Oct. 28 at Ohio Stadium. Credit: Ashley Nelson | Station Manager“The reality is we have to compensate people consistent with the expectations and their performance,” Athletics Director Gene Smith said last week. Ohio State anticipates all 10 assistant coaches will be in the top-three in base salary in the Big Ten at their respective positions, according to a release.Every other returning assistant coach, except for linebackers coach Bill Davis, will receive raises. Davis, who earned $500,000 in his first season as an Ohio State coach, will be paid the same amount in 2018.Offensive coordinator and tight ends coach Kevin Wilson earned a $150,000 raise and will make $800,000 next season. He will have the third-highest base salary of the program’s 10 assistant coaches. Defensive line coach Larry Johnson’s base salary will increase from $575,225 to $750,000 in 2018, making him the fourth-highest paid Ohio State assistant coach. Former Washington State defensive coordinator Alex Grinch was hired as a defensive assistant coach and will have an $800,000 base salary next year. His specific role as an assistant has not been announced. Taver Johnson was hired Tuesday as Ohio State’s cornerbacks coach and will make $345,000 in base salary.In 2018, running backs coach Tony Alford will make $525,000, which is $75,000 more than he made last season. Offensive line coach Greg Studrawa will receive a $90,000 pay bump to raise his base salary to $500,000.Wide receivers coach and recruiting coordinator Zach Smith received a $40,000 raise, but will be the lowest-paid assistant coach, making $340,000. He is the only remaining member of Urban Meyer’s first staff at Ohio State.The Lantern requested contracts of each assistant coach, but has yet to receive the documents, which will include bonuses, supplemental income and other amenities.
Sophomore defensive lineman Jonathon Cooper (18) during the Ohio State vs. UNLV game on Sept. 23. Ohio State beat UNLV 54-21. Credit: Ris Twigg | Former Assistant Photo EditorThe first depth chart of the season was released by Ohio State prior to the season opener against Oregon State.Notable starters include sophomore safety Isaiah Pryor, who acting head coach Ryan Day said was battling with redshirt sophomore Jahsen Wint for the starting position, but has the sole starting position in the safety position opposite junior captain Jordan Fuller.Day also labeled sophomore tight end Luke Farrell as starter, but is marked as a co-starter with redshirt junior Rashod Berry on the depth chart.Junior wide receiver Austin Mack is listed as the starter, with redshirt senior and captain Terry McLaurin at the No. 2 position.Redshirt senior and captain Parris Campbell is listed as an H-Back on the depth chart, along with redshirt junior K.J. Hill and senior C.J. Saunders.At running back, sophomore J.K. Dobbins and redshirt junior Mike Weber are listed as co-starters.On the defensive side, junior Jonathon Cooper and sophomore Chase Young will be co-starters at defensive end alongside junior and captain Nick Bosa.Redshirt junior cornerback Damon Arnette earned the starting spot over sophomore Jeffrey Okudah, though defensive coordinator Greg Schiano said they will rotate.Saunders and redshirt sophomore Demario McCall will be splitting punt returns, and McCall will be doing kick returns with redshirt senior Johnnie Dixon.Freshmen on the depth chart include right tackle Nicholas Petit-Frere, tight end Jeremy Ruckert, Brian Snead and Master Teague at running back, wide receiver Chris Olave, Tyreke Smith and Tyler Friday at defensive end, Taron Vincent and Tommy Togiai at defensive tackle and safety Josh Proctor.Ohio State will play Oregon State on Sept. 1 at 12 p.m. at Ohio Stadium.
Amanda Davis Helps Women Get Behind The Mixer amanda-davis-getting-more-women-color-behind-mixing-board Janelle Monáe’s Front of House engineer spoke to the Recording Academy about the way she’s helping women as young as 16 pursue engineering, working with Monáe, why mentorship is so important to her and moreJennifer VelezGRAMMYs Apr 11, 2019 – 2:33 pm Amanda Davis is on a mission to get women of color behind the mixing board. As the Front of House engineer (FOH) for GRAMMY-nominated superstar musician Janelle Monáe, she’s helped deliver the best sonic experiences at live shows across the world. And the Memphis native isn’t done there; She’s currently also the FOH and production manager for GRAMMY-winning rising star Ella Mai. But Davis didn’t always know live sound was the path she wanted to go down in the music industry; even when she did, she maneuvered the road with little guidance. Thanks to her strong faith and some risk-taking, she’s become a powerhouse engineer who has Tegan and Sara, Jidenna, Wale and more under her FOH repertoire. Now established and knowing the challenges women of color face, she wants to help pave the way for female engineers through a production program called LineCheck! (While all women are welcome to apply, Davis targets women of color as she says they face a particular lack of opportunity in the field.)Davis spoke to the Recording Academy about the way she’s helping young women become engineers through her program and how they can get involved, how she began her career, working with Monáe and why mentorship is so important to her. Tell me about yourself, where did you grow up? When did your interest in music begin?I was born and grew up in Memphis, Tenn. That alone is the best inclination as to where/when my interest in music began. The soul of Memphis is music. I honestly have no idea when/where the interest in music began because that’s all I know. I think I started piano lessons when I was between three and five years old. By the time I was in middle school I realized I could sing and started to focus on that until I was about 23, had a real come to Jesus moment with myself (laughs) and concluded that I didn’t want to sing anymore. I still wanted and needed to be involved in music. So I took a leap of faith and went to audio school. Put in the time, participated in multiple internships and hustled my butt off in Atlanta. Through many trials and errors, here I am six years into a career. How did you begin working with music?I first started working as a lab tech at SAE Institute. Then I started teaching music theory there. While doing that I was working as a FOH at a church and different clubs around the Atlanta area. When did you realize you wanted to be an engineer?It kind of happened organically. I was just trying to find my way through the industry and where I belonged. Becoming an engineer was something I really started focusing on once I was almost done with my time at SAE. How did you begin working with Janelle Monáe?My friend, Jeff Cohran, who’s also Janelle’s tour & production manager, called me and explained that Janelle expressed wanting a woman as her FOH. I immediately sent my resume, mind you, I had never toured at this point in my career so the resume wasn’t really that long (laughs) and the rest is history. Email Twitter Facebook Amanda Davis Is Getting More Women Of Color Behind The Mixing Board News Fondest memory in the studio so far?My second to last internship I got to work with producer Dru Castro. He produced a couple of my favorite songs on an India.Airie album.Talk to me about the LineCheck! Women In Production program you have going on, what is it?LineCheck! is a program I initiated to have a small group of young ladies shadow me during sound checks while I’m on tour. These are young ladies who are pursuing and/or interested in live concert production. Whether that be live sound, tour management, production management, production assisting. It’s to give exposure to this side of things and show them that these positions are viable careers to pursue. I show them stage set up, how I build my show files, explain load ins and load outs, etc. They sometimes even get the chance to speak with other women who are on tour with me in the aforementioned positions. How did this idea come about and what do you hope participants get out of it?When I got the call to go out on tour with Janelle I realized I had no one to call to ask how to do this. I didn’t know how much I should get paid, how to advance, how to build an input list, tune a room….nothing! I had one person I called on, but it wasn’t a woman and he hadn’t really toured on this level, so, unfortunately, I was really winging it! (laughs) So as I grew as a woman and engineer, I realized that I wanted to help those coming along after me so they wouldn’t feel alone and as uneducated as I did starting out on this journey. There are a lot of things I wish someone told me that I just had to learn the hard way. No need for others to go through that way, right?! Who is eligible and how can they get involved?Any young lady 16 years of age and above are welcomed! I will be completely transparent and say I particularly extend this offer to women of color, simply because that demographic is usually deprived of exposure to these types of opportunities, but all are welcome! Email firstname.lastname@example.org to inquire about dates. RELATED: Put Your Dreams To Work: 5 Ways To Land Your Ideal Music JobWhy is this kind of mentorship work important to you? Viola Davis said something at the 2017 Emmys I will never forget, I’m abbreviating a bit but she said, “The only thing that separates women of color from anyone else is opportunity”. I’ll add exposure to that. These young ladies simply don’t know that this career path is even an option for them, I didn’t! I want to do my part to let them know this is an option…there aren’t any limits! What’s the greatest lesson the industry has taught you so far?Trust God, then yourself. What is your advice for young women that want to pursue engineering?Don’t limit yourself to one sector of engineering. There are sooooo many opportunities from mixing live, studio tracking, RF coordinator, patch person, post-production mixing. Much more! It’s really endless. Try it all and see what you organically gravitate towards the most. What projects are you working on now?I’m currently on tour with Ella Mai as Production Manager and Front of House engineer. About to go into heavy touring with my time split between Ella and Janelle. Women In The Recording Studio: Overdubbing History From Her PerspectiveRead more
For representational purposesReuters/Leonhard FoegeAkshaya Tritiya, also known as Akha Teej, falls on the third lunar day of the waxing moon, according to the Indian Vaishakha. In 2019, Akshaya Tritiya will be celebrated on Tuesday, May 7.On this day, many believe that Parusharam, an avatar of Lord Vishnu, was born on Akshaya Tritiya. It is also believed that the sage Ved Vyas began writing the Mahabharat on this day.On Akshaya Tritiya, Hindu households worship the Goddess Lakshmi. They buy cars, houses, and invest in new ventures. Many also buy gold on Akshaya Tritiya believing that the purchase of the jewellery would keep the Goddess happy. One of the reasons to buy gold is to make sure that there are jewellery two months before the Sharavana month which is a favourable time for engagements and marriages. For those not buying gold, who may bring a photo of Goddess Lakshmi’s feet and do a puja for them. Brahmins are advised to donate pots, food, sugar, ghee, for the happiness of their ancestors. Here are some Akshaya Tritiya wishes you can share with your loved ones on an auspicious daySanskrit Word Akshaya means one that never diminishes. May this day of Akshaya Tritiya bring you good luck and success which never diminishes. Happy Akshaya Tritiya.Buying gold is a popular activity on Akshaya Tritiya as it is the ultimate symbol of wealth and prosperity Gold and gold jewellery bought and worn on this day signify never diminishing good fortune. Happy Akshaya Tritiya.Akshaya Tritiya is a very sacred and auspicious day. There is a belief that valuables bought on this special day will bring prosperity, luck and success. So purchase gold of your wish. Happy Akshaya Tritiya.May Lord bless you on this auspicious day of Akshaya Trithiya, and May it be a new beginning of greater prosperity, success and happiness. Greetings on Akshaya Trithiya.
Peugeot logoReutersIn April 2016, French carmaker Peugeot, which is now PSA Peugeot Citroen (Groupe PSA), had confirmed its plans to re-enter India by 2018 as part of the ‘Push to Pass’ plan, a growth plan strategy of the company for 2016 to 2021. The company was in search of an Indian partner and it now looks like it has got one.Also read: Lexus, Kia, Daihatsu, SAIC among seven car makers coming to IndiaFrench website Les Echos reports that Groupe PSA has forged an alliance with New Delhi-based CK Birla Group. The details of the operation are expected to be revealed by Carlos Tavares, the boss of the French manufacturer, at a press conference soon.The tie-up will make use of the Hindustan Motors plant in Chennai as its production unit, the report adds. Hindustan Motors is owned by the Birla family and is one of the oldest carmakers in India with its iconic sedan Ambassador. The plant currently produces some of the Mitsubishi vehicles and has a capacity of manufacturing 12,000 vehicles per year. The first car launch of Peugeot in India is expected before 2020.The French carmaker was one of the early birds in India after the country’s economy opened up for foreign investments in the early 1990s. The company had partnered with Premier Automobiles in 1994 and offered the 309 sedan. However, the partnership ran into trouble with labour issues, and Peugeot wound up its India operations in 1997.After a long hiatus, the second entry was confirmed six years ago, and the company showcased 3008 hybrid, RCZ, 3008 crossover and 908 LeMans car at the Auto Expo 2012. PSA was planning to build a plant worth more than 600 million euros in Gujarat. However, financial uncertainties prompted the company to shelve the plan.Source: Les Echos
Share Federico Parra/AFP/Getty ImagesActivists celebrate Sunday in Caracas after voting in an opposition-organized referendum on President Nicolas Maduro’s plan to rewrite the country’s constitution.Just two weeks before an election to decide the delegates who will rewrite Venezuela’s national constitution, opposition activists held a symbolic vote of their own on Sunday. In the nonbinding referendum, roughly 98 percent of voters rejected President Nicolas Maduro’s plan to replace the constitution.More than 7 million Venezuelans voted in the referendum, according to the local university administrators tasked with overseeing the vote. NPR’s Philip Reeves notes that number — which includes nearly 700,000 expatriots who voted overseas — constitutes about a third of Venezuela’s registered voters.“It’s a way to show how many people are actually against the government, and to give support to people that are actually doing the protests and have been arrested,” expat Andrea de Lima, who participated in South Florida, tells reporter Keyvan Antonio Heydari.Still, Maduro has vowed that Sunday’s referendum will do nothing to stall a July 30 election for delegates for a constituent assembly, which will be responsible for rewriting the country’s 18-year-old constitution. That rewrite would have the capacity to dissolve the National Assembly, an opposition-heavy body of lawmakers that has been a source of frustration for Maduro for years.It was an earlier attempt to dissolve this legislature — an attempt made by the Supreme Court, then quickly reversed in early April — that set off more than 100 days of unrest in Venezuela. The anti-government protests, and their clashes with government security forces, have seen nearly 100 people killed and more than 1,500 injured in the three and a half months that followed.The referendum Sunday was also marred by violence. A 61-year-old nurse was shot dead and three more were injured when men on motorbikes — described by the opposition as members of a “paramilitary” — opened fire on a polling place.Maduro has positioned his proposed constitutional rewrite as a solution to this continuing unrest, calling Sunday’s vote “a meaningless internal exercise.”But NPR’s Philip Reeves notes the unofficial referendum does send a message.“It clearly states that Maduro is as deeply unpopular as he has long been thought to be, and it shows, as the polls have suggested, that Venezuelans are overwhelmingly against the idea of establishing a constitutional assembly,” Philip reports.And NPR’s Greg Allen says that sentiment extends to Venezuelans living in the U.S. One expatriot, Mario Di Giovanni, tells Greg that while the vote isn’t official, the process is supported by Venezuela’s constitution.“So for us it’s binding,” Di Giovanni says, “and we are following the constitution. “Copyright 2017 NPR. To see more, visit http://www.npr.org/.
Share Being deported to an El Salvador he hadn’t seen in more than three decades was a trauma Hugo Castro recalls clearly.The 51-year-old said Monday that his country must begin preparing now to receive the nearly 200,000 Salvadorans who may have to return following the Trump administration’s decision to lift their temporary protected status next year.“The main problem for deportees is that they’re made invisible. They’re rejected, there’s no work. They don’t help us,” said Castro, who was deported from the U.S. in 2015.The U.S. announcement brought fears that a major source of income for this poor Central American nation will be cut off and that families could be separated. But there was also a hint of optimism that Salvadorans with many years of experience in the U.S. could bring expertise and investment to spur the economy.Homeland Security Secretary Kirstjen Nielsen said Salvadorans who have stayed in the U.S. with temporary protected status — only a fraction of the estimated 2 million Salvadorans living there — would have to leave by Sept. 9, 2019, unless Congress came up with a solution allowing them to stay.Twitter via @MaryknollFrsBrsThe temporary protected status program has been offered to citizens from a number of countries fleeing natural disasters or other instability. The affected Salvadorans received the status after earthquakes in 2001 killed more than 1,000 people. Thousands more who arrived in the United States in recent years fleeing gang violence were not eligible.Castro went to the United States as a teenager to study at a college in Atlanta. During his junior year his family back home lost nearly everything when the bank seized their coffee operation. Dropping out, he worked at a country club and a book store and became manager of a Mexican restaurant. Then a run-in with police led to more than two years in immigration detention as he unsuccessfully fought deportation after living in the U.S. for three decades.His first three months back in El Salvador were the worst, he said. He suffered from depression and didn’t want to leave his mother’s home. People told him a 49-year-old man should not depend on his mother to support him, so he started looking for work.“I went everywhere, to restaurants. I told them I had a lot of experience and that I spoke English, but they rejected me,” he said.Eight months after arriving, Castro finally found work at the Salvadoran Immigrant Institute. The non-profit group recognized the value of Castro’s bilingualism and the experience he had gained through the deportation process and it put him to work helping other deportees reintegrate into society.Castro said programs like his are very limited and more needs to be done for returnees.“The government has to get ready, partner with businesses, with all of society, the nonprofits and create assistance programs,” he said.As an example, he noted that in 2016, the country received 52,000 deportees from the United States and Mexico. Meanwhile, a government program to give small cash grants to allow deportees to open their own businesses has only graduated 140 people, he said.The biggest worry among many Salvadorans is that their nation of 6.2 million people will see a big drop in the amount of cash sent home by countrymen working in the United States. Salvadorans transferred more than $4.5 billion from the U.S. in 2016, accounting for 17 percent of El Salvador’s economy, according to government figures.Luis Membreno, an economic analyst in El Salvador, said that fear may be overblown. He said Salvadorans who have protected status in the U.S. tend to be more long-standing migrants who have their families there and send less money home. Many more Salvadorans are not in the program, with growing numbers entering the U.S. illegally over the past decade fleeing violence and poverty.“I don’t think that family remittances are going to fall in the short term,” Membreno said.He also thinks some Salvadoran families in the U.S. could start sending more money back — something that started when Donald Trump was elected president — so remittance figures could rise.In addition, he said, many of those eventually returning could be skilled and have money to invest. “All of this could generate a certain dynamism in the economy,” he said.Cesar Rios, director of the nonprofit group where Castro works, is less optimistic. “Our country is not prepared to receive thousands of Salvadorans,” he said.Deportees are often targeted by gangs, because they believe they have money. Police also target them, because of the stigma that they are criminals.“There’s no work,” Rios said. “Between 200 and 300 Salvadorans continue leaving every day for the United States.”Ernesto Godoy, standing outside a Western Union money transfer office in San Salvador, said he receives money from relatives with protected status in the United States. He worried the decision could lead to bigger problems in El Salvador.“It’s going to affect us, not only me, but on a national level, because here in El Salvador we make ends meet with remittances from the United States,” Godoy said.
LOUISVILLE, Ky. — When the Utah Royals FC unveiled its updated roster on this week, former Louisville standout Gabrielle Vincent was added as a defender to the roster. Vincent earned second team United Soccer Coaches Association all-region honors for the first time in her career. The senior was a starting centerback for the Cardinals all four seasons. She helped guide Louisville to seven shutouts this season, while dishing out one assist. Vincent also served as team captain the last two seasons and helped guide the Cardinals to their best ACC finish and an NCAA Tournament appearance in her final season.Utah Royals FC opens the 2019 season on April 20 at Rio Tinto Stadium against the Washington Spirit. Kickoff is scheduled for 7:00 p.m. MT with a fireworks show to follow after the match. The Utah Royals FC roster currently stands as follows: 2019 UTAH ROYALS FC UPDATED ROSTER (as of April 13, 2019)GOALKEEPERS (3): Nicole Barnhart, Melissa Lowder (NTR), Abby Smith DEFENDERS (11): Katie Bowen (INT-NZ), Rachel Corsie, Sam Johnson, Michelle Maemone (NTR), Sydney Miramontez, Rebecca Moros, Maddie Nolf (NTR), Kelley O’Hara (FED-USA), Becky Sauerbrunn (FED-USA), Gaby Vincent (NTR), MIDFIELDERS (8): Veronica Boquete, Makenzy Doniak, Gunny Jónsdóttir (INT-IC), Lo’eau LaBonta, Amanda Laddish, Taylor Lytle, Diana Matheson (FED-CAN), Desiree Scott (FED-CAN)FORWARDS (6): Alexandra Kimball (NTR), Christen Press (FED-USA), Brittany Ratcliffe, Amy Rodriguez, Katie Stengel, Raisa Strom Okimito (NTR), Erika Tymrak Print Friendly Version Story Links
Tags: Quebec, TRAVELSAVERS Posted by TRAVELSAVERS Quebec now includes over 40 locations Share Tuesday, November 15, 2016 MONTREAL — TRAVELSAVERS continues to rapidly expand in Quebec, with over 40 locations and many others planned for the province.The most recent additions to its Quebec network are: Les Collectionneur du Voyages (Montreal); Les Fou du Voyages (Ste-Julienne); Uniglobe Infinity (St-George de Beauce); Voyges Conceptour (Laval); Voyages Inter Pallas (Montreal); Voyages Le Connaisseur (Montreal); and Voyages Super Prix (Montreal).“We continue to see significant growth in Quebec and great interest from agencies there. Agency owners are keen to have access to our suite of programs, both corporate and leisure,” said Kathryn Mazza-Burney, Executive Vice President Sales, TRAVELSAVERS and The Affluent Traveler Collection.Johan Marjanek, Business Development Manager (BDM), Quebec at TRAVELSAVERS said the main differentiator agencies discover at TRAVELSAVERS is that the program can be customized for each agency based on their needs. “Also, the fact that we offer a dedicated BDM who will take the time to understand each of their needs and assist them in growing their business and building customized marketing plans.”More news: TRAVELSAVERS welcomes Julie Virgilio to the teamThe Quebec team is headed up by Johan Marjanek, Business Development Manager at TRAVELSAVERS Canada, along with Marylene Lupien, Business Analyst and Lydie Rauzon, Manager Special Projects, who is responsible for special projects & translation services.TRAVELSAVERS has rolled out translated versions of its award-winning direct mail program in Quebec. This includes multi-branded lifestyle direct mailers and individual supplier pieces. Complementing this, TRAVELSAVERS has introduced a fully-translated version of its customer loyalty program, Travel Club. The company’s internal extranet, sales and marketing communication and consumer site have also been translated.For more information about TRAVELSAVERS, contact Johan Marjanek at email@example.com. Travelweek Group << Previous PostNext Post >>
24May Rep. Bollin votes to reform car insurance and deliver guaranteed savings to Michigan drivers State Rep. Ann Bollin joined House colleagues today approving a bipartisan plan to deliver significant car insurance rate relief for drivers across Michigan.The House voted to approve legislation guaranteeing lower rates by giving drivers more choice on personal injury protection coverage, sets reasonable fee schedules and fights fraud and abuse.This bipartisan solution is designed to end Michigan’s long tenure as the state with the most expensive car insurance rates in the nation.Reducing car insurance rates has been a top concern of drivers in Livingston County and throughout Michigan. This issue has been discussed for decades and today the Michigan House of Representatives delivered a solution that will lower auto insurance rates to seven million Michigan drivers.Bollin said: “I am proud to play a part in delivering these reforms to drivers in Livingston County and across Michigan. These changes will lower costs, crack down on fraud and provide more coverage choice.”##### Categories: Bollin News
Third, Celsion’s LTSL technology promotes an accelerated release of the drug when and where it will be most effective. That allows for direct targeting of organ-specific tumors. Celsion’s LTSL technology has shown that it’s capable of delivering drugs to the tumor site at concentrations up to 30 times greater than those achievable with chemotherapeutics alone, and three to five times greater than those of more traditional liposome-encapsulated drug-delivery systems. The company’s first drug under development is ThermoDox, which uses its breakthrough LTSL technology to encapsulate doxorubicin, a widely used chemotherapeutic agent that is already approved to treat a wide range of cancers. Currently, ThermoDox is undergoing a pivotal Phase III global clinical trial – denoted the “HEAT study” – for the treatment of primary liver cancer (hepatocellular carcinoma, or HCC), in combination with radiofrequency ablation (RFA). RFA uses high-frequency radio waves to generate a high temperature that is applied with a probe placed directly in the tumor, which by itself kills tumor cells in the immediate vicinity of the probe. Cells on the outer margins of larger tumors may survive, however, because temperatures in the surrounding area are not high enough to destroy them. But the temperatures are high enough to activate Celsion’s LTSL technology. Thus, the heat from the radio-frequency device thermally activates the liposomes in ThermoDox in and around the periphery of the tumor, releasing the encapsulated doxorubicin to kill remaining viable cancer cells throughout the region, all the way to the tumor margin. ThermoDox is also undergoing a Phase I/II clinical trial for the treatment of recurrent chest wall (RCW) breast cancer (known as the “DIGNITY study”), and a Phase II clinical trial for the treatment of colorectal liver metastases (the “ABLATE study”). But most of the drug’s (and hence the company’s) value is tied up in the HEAT study. The HEAT trial is a pivotal 700-patient global Phase III study being conducted at 79 clinical sites under a special protocol assessment (SPA) agreement with the FDA. The FDA has designated the HEAT study as a fast-track development program, which provides for expedited regulatory review; and it has granted orphan-drug status to ThermoDox for the treatment of HCC, providing seven years of market exclusivity following FDA approval. Furthermore, other major regulatory agencies, including the European Medicines Agency (EMA) and China’s equivalent, have all agreed to use the results of the HEAT study as an acceptable basis to approve ThermoDox. The primary endpoint for the HEAT study is progression-free survival – living longer with no cancer growth. There’s a secondary confirmatory endpoint of overall survival, too. Both the oncological and investing community are eagerly awaiting the results, which are due any day now. So then, why are we on the sidelines now, right when the big news is due to hit? That all goes back to why Celsion was such a good investment to begin with, and what it can tell us about finding other big wins in the technology stock market. A Winner in the Making When we’re looking for a strong pick in the biotechnology, pharmaceuticals, and medical devices fields – once we have established the quality of the technology itself and ensured it will likely work as expected – there is a simple set of tests we apply to ensure that we’ve found a stock that can deliver significant, near-term upside. The most critical of these are: The technology must provide a distinct competitive advantage over the current standard of care and be superior to any competitors’ effort that will come to market before or shortly after our subject’s does. In other words, it must improve outcomes, by improving patients’ length or quality of life (i.e., a cure for a disease, or a maintenance medication with fewer side effects), or lower costs while maintaining quality of care (i.e., a generic drug). A therapy that does both is all the better. There must a clear path to market in the short term, or another catalyst to propel the stock upward. An investment in a great technology does not always make for a great investment. You have to consider the quality of the management team and structure of the company, including its ability to pay the bills and get to market without defaulting or diluting you out of your positions. And of course, time. The biggest and most frequent mistake investors make in technology is assuming that it is smooth and short sailing from concept to market. Reality is much harsher than that, and in biotechnology and pharmaceuticals in particular – with a tough regulatory gamut to run – the timeline to take a new technology to market can be anywhere from a decade to thirty, forty, or even fifty years. Liposomes are a perfect example of that. Twenty years ago, I probably could have told you a story about a technology that was very similar to what was laid out above. It would be compelling and enticing to investors of all stripes – a breakthrough technology with the promise to revolutionize cancer care by making chemo less toxic and more effective at the same time. Yet had you invested in that promise alone, chances are you’d be completely wiped out by now, or maybe – just maybe – still waiting for a return. That is why we invest in proof, not promises. So, how does Celsion stack up against our four main proof points? Time to market: When we first recommended Celsion, it was in Phase III pivotal trials. This is the last major stage of human testing usually required before a company can submit an FDA New Drug Application and apply to market the product. The process of bringing a drug to market, even once a specific compound has been identified and proven to work in vitro (in the lab), is perilous. Many things can go wrong along the way. If you look at investing in a company whose drugs are just entering Phase I clinical trials, for instance, it is still unclear if the therapy is effective in vivo (in the human body). This is a critical stumbling block for many companies, whose promising compounds immediately prove less effective or more dangerous than testing suggested. Even if Phase I goes well, it can take up to a decade and sometimes longer to get from there to market with a drug. And then, even Phase II trials often leave treatments five or more years from market – though there are exceptions in cases where a therapy is proven very effective or a disease has so few treatment options available. But shortcuts are rare, and investors have to consider the time and expense (which leads to fundraising and ultimately dilutes your return) of getting from A to Z. In this regard, Celsion made a uniquely great investment. When we first recommended the company, it was in the midst of a pivotal Phase III trial and looked to be about a year or so away from its first commercialization. (Though, speaking to the length of these trials, this one had been started back in 2008.) With many of the most high-profile companies in the industry – those working on vogue treatment areas and conditions, like hepatitis C treatments of late – when they get this close to market, the large banks bid up stocks to high levels, content to squeeze just a few percentage points out at the end. They have to be conservative, since they’re investing large amounts of other people’s money. However, biotechnology is such a fragmented space with far more companies than Wall Street can possibly cover in depth, that coming across a gem like Celsion late in the game with a potentially big win is not as uncommon as you’d think. The “efficient market” hypothesis fails to account for the fact that no one can know everything, including every stock. And Celsion had gone all but unnoticed for some time. Payer acceptability: Celsion has the benefit of developing a 2.0-style product, an improvement over something that already exists. RFA is already in relatively widespread use and has proven effective enough that most every insurance and benefits provider will cover it. Even the early generations of LTSL, while not quite as safe or effective as desired, were enough of a benefit to gather pretty solid support from payers. Celsion, through its clinical trial process, has proven its unique blend is safer, better tolerated by patients, and much more effective than its predecessors. Thus, payer support at a reasonable price is a pretty sure bet. Market size: When we originally recommended Celsion, we stated that the company was sitting on a multibillion-dollar opportunity. And we stand by that statement. However, just because something is eventually worth that amount does not mean it’s bankable today as a short-term investment. So we try to keep our analysis narrowly focused on what can be directly counted on and measured. In Celsion’s case, that’s the Phase III treatment, Thermodox, and the one area in which it is being studied: primary liver cancer (HCC). Even just in this narrow band, however, we see the market opportunity for Celsion as in excess of $1 billion. HCC is one of the most deadly forms of cancer. It currently ranks as the fifth most-common solid tumor cancer, and it’s quickly moving up. With the fastest rate of growth among all cancer types, HCC projects to be the most prevalent form of cancer by 2020. The incidence of primary liver cancer is nearly 30,000 cases per year in the US, and approximately 40,000 cases per year in Europe. But the situation worldwide is far worse, with HCC growing at approximately 750,000 cases per year, due to the high prevalence of hepatitis B and C in developing countries. If caught early, the standard first-line treatment for primary liver cancer is surgical resection of the tumor. Early-stage liver cancer generally has few symptoms, however, so when the disease is finally detected, the tumor is usually too large for surgery. Thus, at least 80% of patients are ineligible for surgery or transplantation by the time they are diagnosed. And there are few nonsurgical therapeutic treatment options available, as radiation and chemotherapy are largely ineffective. RFA has emerged as the standard of care for non-resectable liver tumors, but it has limitations. The treatment becomes less effective for larger tumors, as local recurrence rates after RFA directly correlate to the size of the tumor. (As noted earlier, RFA often fails at the margins.) ThermoDox promises the ability to reduce the recurrence rate in HCC patients when used in combination with RFA. If it proves itself in Phase III, there’s no doubt the drug will be broadly adopted throughout the world once it is approved. A quick look at the numbers: According to the most recent data from the National Cancer Institute, the incidence rates of HCC per 100,000 people in the three major markets are 4 in the US, 5 in Europe, and approximately 27 in China. Based on these incidence rates, the total addressable market in these three regions (which we will conservatively assume to be the total addressable worldwide population for the time being) is approximately 400,000 (12,000 in the US, 40,000 in Europe, and 351,000 in China). Assuming that 50% of HCC patients are eligible for nonsurgical invasive therapy such as RFA, approximately 200,000 patients worldwide would be eligible for ThermoDox. Further assuming an annual cost of treatment for ThermoDox of $20,000 in the US, $15,000 in Europe, and $5,000 in China, in line with similar treatments of the same variety, we estimate that the market potential of ThermoDox could be up to $1.3 billion. Not to mention the countless thousands of lives saved. (And that’s before the rest of the developing world comes online.) Of course, this is an estimate of ThermoDox’s potential assuming 100% market penetration – something that simply never happens. While we expect ThermoDox in combination with RFA to become the standard of care for primary liver cancer, a more reasonable expectation for maximum market penetration after a six-year ramp-up to peak sales (from an expected approval in 2013) is probably 40%. Improving outcomes or lowering costs: This is exactly what the Phase III trial was intended to prove: efficacy beyond a shadow of a doubt. Given preliminary data and earlier trial results, it was already a pretty sure thing, so in our model, we assumed about a 70% chance of success (to be on the conservative side, as always – it’s better to be right by a mile than to miss by an inch). Once we incorporate that probability of success into our model, we come to a probability-weighted peak sales figure in 2019 of approximately $365,000,000 annually. The average-price-to-sales ratio among the big players in biotech these days is about 5. If we apply a sales multiple of 3 (i.e., just 60% of the average) to Celsion’s probability-weighted peak sales for ThermoDox in 2019, we come up with a value for the company of nearly $1.1 billion, which would equate to about $33 per share if it did not issue any new stock between now and then – that’s more than 17 times where the stock was trading when we recommended a buy. And remember, these numbers are only for ThermoDox under the HCC indication. Our Move to the Sidelines With final data from the current Phase III pivotal trial due expected to come in within the next few weeks, Celsion’s stock has ballooned in value from the $2 range to $7.50 or so in the past few weeks. Now, that’s a far cry from the $33 price we mentioned above, but remember, that’s a target for 2019. And it doesn’t allow for a whole range of things that could go wrong. Chief among those concerns is that the Phase III data come in more poorly than expected. Even just a small variance in efficacy or a simple question about safety can knock a few hundred million dollars off those sales figures. Or it can push trials back a year or two, delaying returns and sending short-term-minded investors, like those who have recently bid up CLSN shares, retreating to the hills for the time being. Further downfield there is sure to be competition as well, and of course we may get those miraculous chemo-free treatments mentioned up front. In short, we don’t have a crystal ball and can’t tell you what the world will look like in 2019. If you believe yours is clear, ask yourself if you thought touchscreen phones and tablets would outsell traditional computers by 3 to 1 globally in 2012. If not, you might want to give the crystal a polish. To be clear, the value of Celsion in the near term hinges on a binary event – the results of the ongoing HEAT trial. We are of the opinion that CLSN represents one of the best opportunities we’ve come across since we started this letter, and that the probability of a successful trial is high. Nevertheless, there is substantial down side if the trial is unsuccessful. And it could take years to recover, if ever, on news of a delay from any concerns raised. We’d already advised subscribers to take a free ride early on in our coverage of the stock, taking all of the original investment risk away. However, even with that protection, the short-term potential is still more heavily weighted to the down side. Thus, we booked our profits and stepped to the sidelines on this one. Celsion continues to be a model, even at today’s prices, for a great biotech investment with significant upside potential. But we’re content to wait for the market to hand us another, similar opportunity. The pages of Casey Extraordinary Technology are filled with investments just like Celsion – up-and-coming technology companies the market has yet to discover. Subscribe today and save 25% off the regular price, as always backed by our unconditional money-back guarantee. Bits & Bytes More 3D-Printer Magic (Gizmag) Last week, we noted some of the cool things people are doing with 3D printers. But it’s hard to keep up. The tech is blasting ahead so fast that this week we couldn’t resist adding another. Researchers at the University of Warwick, already known for its cutting-edge tech research, have created a cheap, plastic composite that can be used even with low-end 3D printers to produce custom-made electronic devices. The potential here is staggering. Tablets – Hotter than We Thought (Computerworld) Global market-research company IDC has revised its estimate for sales of tablets for 2012 upward by 4.5%, to 122.3 million units. Apple is expected to lose market share to surging Android-based devices. Whose Internet Is It? (GamePolitics) Well, the US Congress appears to think it’s the people’s. Other countries disagree, and have been trying to wrest control of the ‘Net from our hands for a while now. Many want the UN in charge. But this week, the House unanimously passed a Senate resolution calling on the US government to officially oppose any transfer of Net control to the UN. We’d guess this battle is far from over, though. Tattoo You? (Gizmag) Next time you see a runner with a smiley-face tattoo on his or her arm, you might be looking at a sophisticated metabolic sensor, designed to detect stress due to exertion. Of course, we aren’t always in a smiley frame of mind, are we? So if we could just cross one of these things with a mood ring… We are not ones for bragging about our accomplishments. Whether you believe in such mystical forces as karma or not, it’s generally a good rule that those who take too much credit for their successes are soon rewarded with a streak of the opposite, just to keep them humble. However, it is just as important to take stock in your achievements as it is your failures, if you are going to learn and grow as an investor (or in any pursuit). As such, this week I want to introduce you to the story of a company that we recommended to our investment advisory subscribers back in April 2012. It’s since gone on to gain significantly. The stock rose 297% from our initial recommendation to the day the “sell” call was made. What’s important about this small company is why it made our investment list to begin with, and what its characteristics can tell us about successful speculation in the arena of up-and-coming technology companies. Sincerely, Alex Daley Chief Technology Investment Strategist Casey Research Anatomy of Great Technology Investment By Alex Daley, Chief Technology Investment Strategist Traditional cancer treatment options are little more than a crude mix of “slash, burn, and poison” – that is surgery, radiation, and chemotherapy. There are radical new treatments in labs and trials all over the world that promise to throw out this trifecta; no other disease has received more of the research interest and funding that have defined modern biotechnology over the past three decades. I’m not going to tell you about any of those here. Sure, many of them will be wildly successful and make many investors fabulously wealthy over the next few decades. But most will fail. And those that don’t will take a long time to turn a profit for investors. Yet, there is one small company whose unique twist on cancer treatment is proving to be a major upgrade. We profiled this company in a recent edition of Casey Extraordinary Technology, and it turned in a gain of over 167% for subscribers in just six months’ time. It may yet make billions more still for investors. You see, in recent years chemotherapy has become the core treatment for most cancerous malignancies. And while these toxic cocktails of chemicals have proven effective at destroying cancerous cells, they also have one problem. A big one. Chemo, being essentially a poison, doesn’t just attack cancerous cells – it attacks a broad range of healthy cells too. As a result, the treatment can sometimes be as harmful as the cancer itself in the short run. The side effects are awful, and its use can quickly erode patients’ health. Some have even described chemo as a “cure that’s worse than the disease.” This sad state of affairs for the world’s second most-prevalent chronic disease is why the cancer-research arena has been exploding over the past few years with the goal of developing more targeted, less-toxic therapies – in other words, to do a better job killing cancer cells while leaving healthy cells alone. That’s exactly what Lawrenceville, New Jersey-based Celsion Corp. (CLSN) has the technology to do. And chances are the company is on to one of the biggest cancer-treatment breakthroughs in decades. How It Works Our story starts with liposomes. These nanosized artificial vesicles are made from the same material as our cell membranes – natural phospholipids, i.e., a version of the chemicals that make up everything from fat to earwax, and cholesterol. Not long after their discovery in the 1960s, scientists began experimenting with liposomes as a means of encapsulating drugs, especially cancer drugs. Why? Something called the “enhanced permeability and retention” (EPR) effect. This is a property of certain sizes of molecules – for example, liposomes, nanoparticles, and macromolecular drugs – which tend to accumulate in tumor tissue much more than they do in normal tissues. It’s a useful feature for a cancer drug. Thus, they offer a potential way to combat the two biggest drawbacks of traditional chemotherapeutics: systemic toxicity and low bioavailability at the tumor site. In other words, the drugs now employed are themselves are toxic to normal cells, and they tend to get largely used up before they even reach the tumor site. Early attempts to encapsulate drugs inside liposomes did an okay job of dealing with the toxicity issue, but bioavailability at the tumor site was still limited. Our immune system saw to that. Just like virtually anything else artificial we put into our bodies, traditional liposomes were seen as invaders. Thus, they were rapidly cleared by the mononuclear phagocyte system, the part of the immune system centered around the spleen (yes, we do use it) that destroys viruses, fungi, and other foreign invaders. However, a breakthrough arrived when scientists came up with a new way to sneak these artificial compounds into the body undetected by our defenses. The process gave us what are call “PEGylated” liposomes, with a covalent attachment of polyethylene glycol polymer chains. The effect of attaching these little plastic chains to the end of the liposome was to create a “stealth” liposome-encapsulated drug that was hardly noticed by the system. Problem solved, right? Well, not exactly. A lot of hard work went into getting drugs into liposomes to reduce toxicity, then a bunch more into stopping our immune system from kicking in. But there was still yet another problem. The drug-release rates of these stealth liposomes were generally so low that tumor cells barely got a dose. Scientist had made them so stealthy that they even skated right by cancer cells, usually failing to kill off the tumors. After decades of experimenting with liposome-encapsulated cancer drugs, scientists still had not been able to safely deliver therapeutic concentrations of the chemotherapy drugs to all tumor cells. They had to devise a way to induce drug release when and where it would be more effective. The next big idea came in more recent years, as scientists devised temperature-sensitive liposomes. Heat them and they pop, releasing the drugs just when you need them to. From stealth to non-stealth in a matter of seconds, and right on target. Fortunately, they were able to make it work, but unfortunately, not at temperatures that didn’t essentially cook patients from the inside – sort of defeating the purpose of keeping the chemo at bay to reduce collateral damage. They failed to perform at tolerable levels of heat or time. Fifteen minutes of baking and still only 40% or so of the drug was released, and it took temperatures up to 112° Fahrenheit. It might not sound like much, but it was enough to be intensely painful and damaging as well. That’s where Celsion came in. It’s designed and developed a novel form of these temperature-sensitive chemo sacks – the first of their kind to work effectively and safely – otherwise known as a lysolipid thermally sensitive liposome (LTSL). Celsion’s liposomes are engineered to release their contents between 39-42° C, or 102.2-107.6° F (thus, another translation of LTSL has become “low-temperature sensitive liposome”). And they release the contents at an extremely fast rate, to boot. A Better Way to Use Chemo These unique properties of Celsion’s LTSL technology make it vastly superior to previous liposome technology for a number of reasons. For starters, the temperature range is much more tolerable to patients and won’t injure normal tissue. Payers should be easily convinced to cover the new therapy at profitable rates. In the modern world of health care, failure of a treatment to garner coverage from government medical programs like Medicare and the UK Health Service, and private insurance companies (which generally cooperate closely to decide how to classify and whether to cover a treatment) is usually a game-ender. Payers have a responsibility not just to patients but to their shareholders or taxpayers to stay financially solvent. This means that if a therapy does not provide a compelling cost/benefit ratio, then it won’t be covered. For instance, if you release a new painkiller that is only as effective as Tylenol and costs $1,000 per dose, you’re obviously not going to see support. Second, the temperature range takes advantage of the natural effect mild hyperthermia has on tumor vasculature. Numerous studies have shown that temperatures between 39-43° C increase blood flow and vascular permeability (or leakiness) of a tumor, which is ideal for drug delivery since the cancer-killing chemicals have easy access to all areas of the tumor. These effects are not seen at temperatures below this threshold, and temperatures above it tend to result in hemorrhage, which may reduce or cease blood flow, hampering drug delivery. It’s the Goldilocks Effect: The in-between range is perfect. The market must be measurable and addressable. There must be some way to say specifically how many patients would benefit from a therapy, and to ensure that those patients have providers caring for them that would make efficient distribution of the therapy possible. For instance, a successful treatment for Parkinson’s disease might be applicable to hundreds of thousands of patients, with little competition from other treatments, whereas a treatment for Von Hippel-Lindau (VHL) might only reach hundreds. If the goal is to recover years of research investment and profit above and beyond that, then market size matters, as do current and future competitors that might limit your reach within a treatment area.
People with HIV have been failed by the government’s new disability benefit, according to new research.The research by the National AIDS Trust (NAT) found that only three-fifths of people living with HIV were found eligible for the new personal independence payment (PIP) after being reassessed.NAT says its research has confirmed long-standing fears that people with HIV would not receive the support they needed under PIP, which is supposed to help cover people’s extra disability-related costs.Its report shows that only three-fifths (63 per cent) of the 1,000 people with HIV who were previously receiving disability living allowance (DLA) and had been reassessed for PIP were awarded the new benefit.This compares with 73 per cent of all DLA claimants who had been reassessed and were awarded PIP, according to the figures, published by the Department for Work and Pensions (DWP) last December.One charity that works with NAT, River House, described yesterday (Wednesday) how a 57-year-old man who was diagnosed last October with HIV and also had chronic obstructive pulmonary disease, had been awarded zero points after a PIP assessment in April.An appeal to the Department for Work and Pensions (DWP) – the so-called mandatory reconsideration stage – was refused in late June.By this time, his health had deteriorated even further and he was admitted to hospital, where he was diagnosed with untreatable lung cancer.He was due to receive DWP’s decision on a fresh PIP application this week, but died on Monday morning.Another River House service-user with HIV has described how he had to start using foodbanks after his PIP was suddenly stopped because he missed a renewal deadline by just two days after he was diagnosed with cancer.DWP refused to reconsider removing his PIP and he had to wait more than 16 weeks to be assessed again.He said: “From the moment that my PIP stopped, I lost the uplift in my ESA [employment and support allowance] that I received because I was now not receiving PIP.“While I waited to be assessed for PIP and again for ESA, I had to borrow small amounts of money from friends [and] organisations that support people living with HIV and I was a regular visitor to local food banks.”The NAT analysis also shows that people with HIV who had been claiming DLA were more likely (43 per cent) than the average DLA claimant (30 per cent) to see their level of support cut if they were awarded PIP after a reassessment.According to last December’s figures, only about 1,000 of the 7,920 people living with HIV who were claiming DLA at the start of the PIP rollout in 2013 – which itself was about 10 per cent of all those with HIV in the UK – had been reassessed.The charity says that not everyone living with HIV in the UK has benefitted equally from modern treatments – for example, long-term survivors and people diagnosed late – and some will have life-long health problems as a result of HIV. One study found that two-thirds of people living with HIV in the UK have at least one other condition, in addition to HIV, and 38 per cent have more than one additional condition.Deborah Gold, NAT’s chief executive, said: “The evidence so far is that PIP is not working for people living with HIV who need extra support.“The assessment is not fit for its stated purpose, to identify the disability-related barriers to participation and independence experienced by people living with HIV. “The tick-box eligibility criteria describe only the most basic aspects of existence, such as physical capacity to consume food and bathe, without any understanding of the social context of life with a serious long-term condition.”Among the charity’s many concerns about the assessment process are that it fails to accurately capture: the risk of isolation due to HIV-related anxiety; the need for support with nutrition; and the importance of adhering to HIV medication.Sarah Radcliffe, NAT’s director of policy and campaigns, said that the research – the first to be carried out into the impact of PIP on people with HIV – shows that the concerns raised when the abolition of working-age DLA was announced in 2010 were not baseless.She said the way the assessment was devised “means people living with HIV will not have their support needs identified – or where they are picked up, this will not necessarily translate to support”.And she said the social model “rhetoric” used by DWP when it introduced the new benefit – focussing on how social factors create barriers to participation for disabled people – “has not translated to reality for PIP”.Instead, she said, the PIP assessment “looks a lot like the work capability assessment’s notorious ‘tick box’ medical approach”.She added: “The descriptors used are proxies for a basic existence and not for barriers to participation or the extra costs associated with an active, independent life.“It is not too late to improve PIP for people living with HIV. The vast majority are yet to be reassessed. “It is time to look again at PIP, from scratch, and make sure it lives up to its stated goals of promoting participation and independence.”A DWP spokeswoman said in a statement: “We introduced PIP to replace the outdated DLA system – it takes a much wider look at the way someone’s health condition or disability impacts them on a daily basis and is tailored to suit each individual’s needs.“Decisions are made following consideration of all the information provided by the claimant, including supporting evidence from their GP or medical specialist.“Under PIP, 28 per cent of claimants are now receiving the highest rate of support, compared to 15 per cent under DLA, and anyone who disagrees with a PIP decision has the right to appeal.”But DWP figures from last December also showed that fewer than half (about 126,000) of the 254,000 people previously receiving the higher rate mobility component of DLA secured the same level of mobility support when reassessed for PIP.And unpublished DWP figures obtained by DNS in March showed nearly half of disabled people subject to “planned reviews” of their eligibility for PIP were having their existing award either cut or removed completely.NAT has produced free resources on PIP for people living with HIV and the services who support them
Learn how to successfully navigate family business dynamics and build businesses that excel. Eddie Antar died this weekend at age 68. Register Now » Jason Fell News and Trends Free Webinar | July 31: Secrets to Running a Successful Family Business Director of the Entrepreneur Partner Studio Eddie Antar (R) once known as Crazy Eddie Next Article September 12, 2016 Eddie Antar was an entrepreneur who realized the highs of business success as well as the lows of fraud and running from authorities. You might not recognize his name, but if you were alive in the late 1970s and 1980s, you’d be hard pressed not to know his business: he was the founder of the Crazy Eddie discount electronics store chain.From his quirky TV and radio commercials, how could you forget that his prices were totally “inasaaaaaane!”Antar died on Saturday. He was 68.Born in 1947, Antar opened his first Crazy Eddie electronics store when he was in his early 20s, in Brooklyn, N.Y. With the help of his popular commercials – which aired for nearly 15 years and starred radio personality Jerry Carroll – the business grew into a small empire of stores up and down the East Coast. VCRs, video games and camcorders (remember those?) were hot sellers at the time.But Antar’s “success” wouldn’t last forever. Here’s a quick look at 11 moments during his rise and fascinatingly bizarre fall:Antar opened his first Crazy Eddie electronics store in 1969 on Kings Highway in Brooklyn.The term “crazy” came from Antar’s wild sales style. Apparently, he’d accept customers’ shoes as deposits on items like TVs or stereos.His first commercial aired in 1975. Each one ended with the phrase, “’Crazy Eddie, his prices are insaaaaaane!” He continued to open new locations in the New York metro area.Riding the brand’s popularity (those ads were memorable), Antar took the company public in 1984.At its height, the company had more than 40 locations from Boston to Philadelphia, and was generating as much as $350 million in revenue a year.By 1987, stockholders discovered that $45 million in merchandise was missing. His business and accounting practices were called into question and the stockholders staged a takeover of the company. After all, how could he have such insanely low prices?Federal prosecutors eventually charged Antar and his family of skimming cash and manipulating the company’s stock.In 1989, Crazy Eddie filed for bankruptcy and its final store closed.The following year, Antar fled the country and was later found living in Israel. He was extradited and served seven years in U.S. prison.Antar’s cousin, Sam, who was the company’s CFO, pleaded guilty to fraud and later served as a consultant to governmental agencies that were investigating accounting fraud.In 2001, a newly freed Antar attempted to bring Crazy Eddie’s back, selling electronics online. Despite the cheesy ads, there wasn’t enough steam in the brand for a second go and the company failed. Add to Queue –shares 11 Insaaaane Things You Didn’t Know About the Founder of Crazy Eddie 3 min read Entrepreneur Staff Image credit: Sven Nackstrand/AFP | Getty Images
While audio advertising has been relatively consistent for the better part of 50 years, it’s now going through a massive transformation. It’s no longer as simple as putting out a big (and often impersonal) ad campaign in an effort to reach the people you’re trying to reach. Today, it’s all about reaching the right people via the right platform at precisely the right moment while giving them a much more targeted and personalized experience.Over the past 15 years, we’ve watched the industry progress from “radio” to “audio” and the strengths of the medium develop from reliable to innovative. In the spirit of reflection, it’s interesting to examine just how much audio advertising has evolved.These are some of the biggest changes we’ve seen:Opportunities GaloreIt’s hard to imagine, but before 2000, the mainstays of today’s audio landscape barely existed– satellite radio, streaming and podcasts were just starting to emerge. Of course, these channels have exploded in popularity and continue to evolve rapidly, opening up a dearth of opportunities for brands to connect with new audiences. Unlike TV and digital ads, audio ads don’t have to compete with other ads for eyeballs or work within the space confines of a screen.Today’s listeners are much more tuned in and engaged with what they’re listening to, providing greater opportunities for advertisers to reach them.Podcast listeners, for example, have been shown to be so invested in their favorite shows that they actively listen to ads contained within the episode. And, if a podcast host endorses a particular product, even better as listeners tend to be more open to the product. Even with the availability of ad-free streaming services, millions of listeners opt to listen to the ad-supported versions of Spotify and Pandora, again giving brands the chance to share their products and services with a more engaged audience.Content ExplosionNaturally, the rise of these opportunities goes hand in hand with the explosion of audio content. While years ago talk radio dominated the audiowaves, podcasts are taking center stage. There are over 600,000+ active podcasts shows catering to just about every topic or interest imaginable.With podcasts, listeners hear exactly what they want to hear, exactly when they want to hear it, giving advertisers the ability to reach exactly who they want to reach when they want to reach them.One of the biggest advantages for an advertiser of endorsed audio is the “host trust factor.”When your favorite host or influencer tells you how much they love a product or service, loyal listeners activate and buy that product or service.More FragmentationOf course, with more opportunities and content comes more fragmentation. From 1922 when the first radio ad ran to even 10 years ago, AM/FM radio was a straight shot for an advertiser looking to connect with Americans en masse.But with so many opportunities to reach target audiences today, how do advertisers decide where to invest their dollars? Yes, audiences are much more engaged, but what about search and discovery? With 120,000 podcasts launched in the last year alone how do advertisers find the shows or identify the hosts or influencers that will best align with their products?One big way advertisers are combating these challenges is through AI. AI technology (like our aiWARE platform) can surface tons of data to find what’s most meaningful to brands, discover new content, find the right podcast influencer and help guide brands to making smart, cost-effective decisions around their ad spend.What’s On The Horizon?As we usher in 2019, we look forward to watching the audio advertising landscape continue to evolve. We expect that audio content, especially podcasts and voice-enabled devices, will become more unique and personalized.We also expect podcasts will continue to become mainstream and even get closer to finding the listener (instead of the listener looking for the podcast).While these opportunities and content expand, we believe that AI will continue to guide audio advertisers on their quest to delivering a more meaningful and personalized customer experience.If we’ve learned anything in the last few years it’s that the audio space is full of surprises. As the industry continues to innovate, advertisers will need to keep pace and challenge themselves to take full advantage of the opportunities that await. Thirty years in the media business and involved in over $1 billion of ad campaigns.One thing is certain, AUDIO IS BACK! The Evolution of Audio Advertising and What’s Next in 2020 Zeus PeleusesJune 3, 2019, 8:23 pmJune 3, 2019 AIAudio AdvertisingAudio Contentcontent marketingpodcastsprogrammatic advertisingRadio AdvertisingTV adsVeritone One Previous ArticlePernix Launches Attribution Application Solution to Brings Full Transparency to Performance Marketing ProgramsNext ArticleUpland Software Acquires Kapost, Raises Guidance